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        Millions of people, especially Southeast Asians, are affected by beta thalassemia, a disease characterized by abnormal synthesis of hemoglobin followed by excessive extravascular hemolysis. Patients with beta thalassemia major have severe hemolysis and must receive regular blood transfusions and iron chelation therapy. Without iron chelation treatment, iron overload occurs because    
    
        
     
             
                             
                             
                            
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